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KMID : 0870420080120020124
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2008 Volume.12 No. 2 p.124 ~ p.127
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Incidental Intraductal Papillary Mucinous Neoplasms(IPMN) of the Pancreas after Liver Transplantation
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Kim Kwan-Il
Suh Kyung-Suk
Lee Kuhn-Uk
Jang Jin-Young
Kim Sun-Whe
Yi Nam-Joon
Shin Woo-Young
Kim Se-Hyung
Kim Ju-Hyun
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Abstract
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Purpose: The incidence and risk of malignancy are elevated in solid organ transplant recipients compared to persons in the general population. Epidemiological data reveal that the length of exposure to immunosuppressive therapy and the intensity of therapy are clearly related to the post-transplant risk of malignancy. The purpose of this study was to investigate the course of incidental intraductal papillary mucinous neoplasms (IPMN) of the pancreas after liver
transplantation.
Methods: We retrospectively reviewed the medical records of 17 patients with IPMNs of the pancreas who underwent liver transplantation between January 2000 and December 2006. The mean follow-up duration was 29.6 ± 22.8 months.
Results: The mean patient age was 55.2 ± 7.2 years, and the male to female ratio was 14:3. All patients had branch duct type IPMNs. The lesions were located principally in the head (64.7%) and body (52.9%) of the pancreas. The mean tumor size was 13.0 ± 6.2 mm. There were no newly developed symptoms associated with these lesions, and none of the lesions enlarged during the follow-up period. No patients underwent surgical resection of their lesions.
Conclusion: The course of each of the incidental small IPMNs of the pancreas was uneventful for more than 2 years after liver transplantation. Therefore, patients with incidental small IPMNs of the pancreas are not immediate candidates for surgical pancreas resection. However, a longterm follow-up study with a larger sample size will be required to establish treatment guidelines in immunosuppressed patients.
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KEYWORD
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Pancreas cystic lesion, Intraductal papillary mucinous neoplasm, Live rtransplantation
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